STIFFNESS

PROFILE

Repeating waveform matrix without solid framework structures considerably reduces device stiffness and is comparable to the material stiffness of PEEK

OSSEOINTEGRATION

Proprietary surface treatment produces micro and nano surface topographies that are beneficial for cellular attachment and bone growth1

ADAPTIVE

MATRIX

Edge-to-edge uniform porosity disperses dynamic loading on the vertebral endplates providing a unique Snowshoe Effect™ that allows bone to adapt to the device2

SURFACE ENHANCED STRUCTURALLY ADVANCED

MACRO  STRUCTURE

neoWave™ consists of a 3D-printed consistent waveform matrix that reduces stiffness and provides a load-dispersing Snowshoe Effect™ to lessen the potential for implant subsidence. This uniformly-porous architecture contributes to a device stiffness that is comparable to the material stiffness of cortical bone and PEEK while increasing bone graft volume and providing a lattice for bone ingrowth.

LEARN MORE ABOUT neoWave™ ARCHITECTURE

MICRO SURFACE

The proprietary micro roughness of the neoWave™ surface has been shown to be favorable for bone attachment and ongrowth.1 The novel surface design, manufacturing, and post-processing techniques all contribute to the beneficial environment for cellular proliferation.

LEARN MORE ABOUT neoWave™ OSSEOINTEGRATION

NANO SURFACE

Cellular response to a material’s nano surface characteristics plays an important role in overall bone apposition and proliferation.3 The proprietary nanotopography of the neoWave™ surface has been shown to support rapid cellular attachment, communication, and propagation.1

LEARN MORE ABOUT neoWave™ CELLULAR RESPONSE

Strength Under Impaction

The patented neoWave™ matrix uniquely dampens impaction loads providing exceptional mechanical integrity to withstand forces during implantation, which has been found to be problematic for some competitive 3D-printed devices.4 In this video, the same sample was impacted into four locations with over 70 aggressive mallet strikes with no visible fractures or deformations and no visible wear debris or flaking.

Stiffness Profile

Most titanium cage designs require solid framework in order to meet the mechanical demands during insertion and postoperative loading. These structures increase stiffness and create loading “hot spots” that can promote subsidence. neoWave™ features a proprietary uniform matrix that decreases stiffness and allows the implant to evenly deflect under compressive loads to mimic a more natural bone-like response.

Engineering mechanical modeling has shown machined titanium to be up to 13x stiffer than neoWave™.5

Structural Waveform

The proprietary neoWave™ matrix is comprised of a repeating pattern of internal wave-shaped structures that contributes to the reduction in device stiffness yet enhancement of structural strength and durability. Many competitive 3D-printed implants require solid framework to overcome their structural integrity deficiencies.

Structural Waveform

Ti3D Structural Waveform is designed to reduce the stiffness of the device by deflecting the load through internal wave shaped members, contributing to the ideal stiffness profile; while providing a structurally sound network for strength and durability.

Other 3D printed cages require solid framework to provide mechanical support to hold up to the stresses applied on insertion and postoperative loading.

Subsidence vs. Graft Surface Area

Historically, many interbody manufacturers have attempted to increase internal bone graft volumes by thinning the outer walls of the implant at the cost of concentrating compressive loads over a smaller contact area, which increases the chance for subsidence.

The neoWave™ matrix solves this problem by uniformly spreading compressive forces throughout the implant while maintaining substantial bone graft volume.

Testing has shown that neoWave™ reduces subsidence by 31% at peak loads despite a 29% greater amount of bone graft volume compared to a PEEK interbody implant of an identical footprint.

Osseointegration

Firm anchoring and boney incorporation of an interbody device is a key factor in creating a successful fusion. The continuous cephalad/caudal porosity of the neoWave™ matrix allows for consistent boney ingrowth throughout the entirety of the implant.

Sheep Study – bilateral femur model

Bone In-Growth Model
Bilateral model with 20 year history in SORL, Sydney Australia

Sample size at 4 and 12 weeks
Cortical sites:  n=6
Cancellouis sites:  n=4

Endpoint Sites
Cortical sitese:  Shear strength, histology
Cancellous sites:  Histology

4 Weeks

12 Weeks

Bone Apposition at 12 Weeks

4 Weeks

12 Weeks

Bone Apposition

Cellular Response

Surface topography at the micro and nano levels have been shown to play an important role in cellular attachment and the creation of an environment conducive to bone growth.3 A cellular response study conducted by distinguished Professor Bill Walsh at the Surgical and Orthopaedic Research Laboratory found that the proprietary neoWave™ surface topography supported rapid cellular attachment and bone cell proliferation.

1 Hour

5 Hours

20 Hours

1 Data on file provided by Bill Walsh, PhD

2 Data on file provided by Anthony Valdevit, PhD

3 Olivares-Navarrete, R., Hyzy S.L., Gittens, R.A., Berg, M.E., Schneider, J.M., Hotchkiss, K., Schwartz, Z., Boyan, B. D. Osteoblast lineage cells can discriminate microscale topographic features on titanium-aluminum-vanadium surfaces. Ann Biomed Eng. 2014 Dec; 42 (12): 2551-61.

4 Donovan, Bill. “Updating IFU’s for Stryker’s 3D Tritanium Implant.” Orthopedics This Week, vol. 15, no. 9, 12 March 2019, pp. 11-15. 

5 Data on file